Abstract

BackgroundTakayasu arteritis is a rare systemic vasculitis, which affects the aorta and its major branches, especially in young females. Diagnosis and treatment for Takayasu arteritis with coronary stenosis are important to prevent fatal complications. Immunosuppressive treatment such as corticosteroid is a common treatment for this condition. However, the effects of immunosuppressive treatment on inflammatory coronary stenosis caused by Takayasu arteritis remains unknown.Case presentationAn 18-year-old female had chest oppression on effort and was referred to our hospital due to ST-segment depression in I, aVL, and V2–4 on electrocardiogram. Coronary angiography showed severe stenosis in the ostium of both the left main trunk and the right coronary artery. 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography showed isolated inflammation of the aortic root. She was diagnosed with Takayasu arteritis and treated with combined immunosuppressive treatment with corticosteroid and tocilizumab, which decreased the FDG uptake in the aortic root. Four months after initiation of the immunosuppressive treatment, coronary angiography showed regression of the coronary ostial stenosis. Coronary artery bypass surgery was considered, but the patient rejected invasive revascularization for coronary artery disease. She did not have chest oppression or ST-segment depression after the immunosuppressive treatment. She had no cardiac events for 6 months after discharge.ConclusionsWe described regressed coronary ostial stenosis in a young female patient with Takayasu arteritis. Immunosuppressive treatment might have a favorable effect on coronary ostial stenosis in Takayasu arteritis.

Highlights

  • Takayasu arteritis is a rare systemic vasculitis, which affects the aorta and its major branches, especially in young females

  • We present a rare case of a young female with Takayasu arteritis who had regressed coronary ostial stenosis after immunosuppressive treatment and was evaluated by repeated coronary angiography and 18F-FDG positron emission tomography (PET)/computed tomography (CT)

  • In the present case, coronary ostial stenosis of Takayasu arteritis was regressed after immunosuppressive treatment

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Summary

Conclusions

We described regressed coronary ostial stenosis in a young female patient with Takayasu arteritis.

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