Abstract
Gastric cancer stands among the most common causes of cancer death worldwide (1). Median overall survival (OS) for patients with advanced disease is approximately 1 year and chemotherapy still represents the milestone of treatment in most patients (2). While first-line chemotherapy has a well-established role in gastric cancer management, during the past few years several trials clearly demonstrated a significant OS benefit for second-line therapy compared with best supportive care (BSC) alone (3); however, as the gain in survival is at best modest in absolute terms, a careful clinical selection is needed to identify patients who could benefit from salvage therapies (4). Moreover, no standard treatment exists after second-line failure. Thus, searching for new therapeutic opportunities in pretreated advanced gastric cancer patients is imperative for researchers and clinicians.
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