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Abstract
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Highlights
Much of what we study is related to complications in pregnancy
Few studies have yet considered how this selection may distort the long-term associations of reproduction with women’s later health. It seems that studies of pregnancy outcome and long term health aspects both for the child and the mother by large benefit from the reproductive data of the mother: risks related to the pregnancy or the child need to be evaluated through knowledge of the mother’s previous pregnancies, while long term risks related to the mother herself calls for her complete reproductive history
Leiv Bakketeig, and his colleague Howard Hoffman from the US (NICHD, Bethesda), saw early the value of sibship data as the basis for research, and they published a series of unique papers in the period 1975-1986. Their focus was mostly on recurrence of perinatal events in successive sibs like small-forgestational age (SGA), preterm birth (
Summary
For more than three decades, sibship organized data from the Medical Birth Registry of Norway have been the basis for studies of variation of pregnancy outcome. The chances that a woman has a pregnancy are contingent on the outcome of prior pregnancies in several important ways: women with a medically complicated pregnancy may be advised or choose to avoid further pregnancies; women who are mothering children with health impairments resulting from perinatal complications may be too overwhelmed to bear another child; and underlying medical factors (such as insulin resistance or vascular dysfunction) associated with pregnancy complications may be associated with secondary infertility These factors add up to a strong potential of selection bias when only first births are considered. The long lasting registration of all births provides a setting for studies of variation of longevity of mothers and fathers as a function of their complete reproductive history Such data are almost impossible to achieve outside the Nordic countries. Recurrence of specific pregnancy outcomes within sibships and between generations provide new knowledge [8,9,10,11]
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