Abstract
AbstractThe regioselectivity of the conjugate nucleophilic addition of amines to vicinal di‐acceptor‐substituted alkenes has been studied. A set of results obtained with standard primary and secondary amines gives some clues on the relative acceptor character of classical electron‐withdrawing groups (EWG). We have shown in addition that computed inverse local nucleophilicity index can be used to predict the regioselectivity of the nucleophilic attack.
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