Regioselective synthesis of pentasubstituted benzene derivatives: TBAF as an effective catalyst for the sequential Michael addition-intramolecular aldolization

Abstract

Polysubstituted benzene derivatives were synthesized starting from the Baylis–Hillman adducts via the sequential introduction of primary nitroalkane at the primary position, Michael addition to β-branched Michael acceptor, aldol condensation, elimination of nitrous acid, and the final aromatization process.