Abstract
AbstractThe synthesis of highly enriched C‐2 deuteriated and tritiated (E)‐5‐succinimido‐4‐oxo‐pent‐2‐enoic acid for use in enzymatic reduction is described. The starting materials 3‐methoxycarbonyl‐[3‐2H]propionyl chloride and 3‐methoxycarbonyl‐[3‐3H]propionyl chloride were prepared in high yield by regioselective deuteriation or tritiation of monomethyl succinate. The synthetic route involved regioselective bromination of 5‐succinimidolaevulinic acid followed by dehydrobromination.
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