Abstract
In recent years free radical cyclization has emerged as one of the versatile and simplest methodology for the construction of carbon-carbon bond in organic synthesis. In multi-step synthesis its use is significant as the key step of the synthesis involve the formation of carbon-carbon or carbon-hetero bond employing radical cyclization strategy. Regioselective synthesis of heterocycles viz. uracil, pyrone, coumarin, quinolone indole, benzofuran-annulated oxygen, nitrogen and sulfur heterocyclic compounds by tri-n-butyl tin hydride and thiol-mediated radical cyclization will be presented.
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