Abstract
The first regioselective resin-anchoring reaction of 2,4,6-trichloropyrimidine has been achieved through 4-amino-de-chlorination by solid-supported Boc-like N-potassium carbamates. Excellent regioselectivities together with high coupling efficiency were obtained with aliphatic, aromatic and α-amino-ester derived carbamates. The scope and limits of the reaction are described with the view of its applications to the solid-phase synthesis of combinatorial libraries of aminopyrimidine-based structures.
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