Abstract
A new pattern for nitrative cyclization of 1,6-enynes with t-BuONO has been reported for the synthesis of various 2-pyrrolidinone derivatives in 45–88% yields. This novel method is operationally simple and proceeds under very mild conditions without using any additives. The reaction pathway involves nitro radical addition toward an alkenyl group/5-exo-cyclization/H-abstraction sequence, allowing a highly regioselective and practical protocol toward the formation of new C–N and C–C bonds.
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