Regioselective introduction of vinyl trifluoromethylthioether to remote unactivated C(sp3)—H bonds via radical translocation cascade

Abstract

Described herein is an efficient protocol for the regioselective introduction of a vinyl trifluoromethylthioether to remote unactivated C(sp3)–H bonds. The cascade process involves the vinyl radical-mediated 1,5-hydrogen atom transfer (HAT) and remote vinyl migration. During the transformation, inert C–H and C–C bonds are consecutively cleaved under mild conditions. The reaction features good functional group tolerance, broad substrate scope, and high regio-/stereo-selectivity.