Regioselective deacetylation of secondary acetyl esters in peracetylated methyl glycopyranosides by aspergillus niger lipase

Abstract

Peracetylated methyl β,α- d-glucopyranosides ( 1,2), methyl β,α- d-galactopyranosides ( 3,4) and methyl α- d-mannopyranoside ( 5) were transformed into the corresponding triacetates with one secondary hydroxyl group and diacetates with two secondary hydroxyl groups by the regioselective hydrolysis of A. niger lipase in 0.1M phosphate buffer/acetone solution.