Regioselective Alkylation Reactions of Enamines Derived from Phosphane Oxides − Synthesis of Phosphorus Substituted Enamino Esters, δ-Amino-phosphonates, Pyridone Derivatives and Pyrroles

Abstract

α-Substituted (2-iminoalkyl)phosphane oxides were obtained from the azaenolates of imines or enamines and alkyl halides. The functionalized imines or enamines thus obtained were used for the synthesis of δ-amino esters, δ-amino phosphonates and heterocycles such as 3,4-dihydropyridin-2-ones, 2-pyridones and pyrroles containing a phosphinyl substituent.