Abstract
The pulmonary vascular response to hypoxia was studied in open and closed chest anaesthetised sheep. Control distributions of pulmonary blood flow were significantly different between the open and closed chest animal, and changes in total pulmonary vascular resistance during hypoxia were identical in the two preparations. There were, however, marked regional differences in the response of the pulmonary vasculature to hypoxia in both preparations, there being greater increases in vascular resistance in the central zone of the lungs between the dorsal and ventral surfaces of the supine animal.
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