Abstract
Segments of renal and carotid arteries from F (129-139 days gestation; term 145 days) and N (5-7 days) sheep were mounted for isometric tension recording in Krebs solution at 37°C, aerated with 95% O2 - 5% CO2 gas mixture. After establishing optimal resting tension, changes in wall tension following cumulative additions of exogenous norepinephrine (NE) were studied. Contractile force generated was corrected for cross-sectional area of the segment (mN/mm2) and expressed as mean ±SE.Results demonstrate that: 1) sensitivity to NE is unchanged in renal and carotid arteries from F to N life; 2) however, contractile force generated in the renal artery of N is greater than F, but no different in carotid arteries of F compared to N; and 3) developmental patterns of arterial responses to NE differ among blood vessels, suggesting that rapid changes in arterial smooth muscle reactivity to circulating catecholamines occur during the perinatal period.
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