Abstract
Background Non-ischemic cardiomyopathy (NICM) is a common cause of left ventricular (LV) dysfunction and may be associated with myocardial fibrosis. Global LV systolic function may underestimate the impact of fibrosis on myocardial function and is insensitive to regional abnormalities in myocardial motion. Advances in cardiac MRI have enabled quantification of myocardial fibrosis through the calculation of the gadolinium extracellular volume fraction (Ve) using T1 mapping techniques employing the modified look-locker inversion recovery (MOLLI) correction. In addition, tissue phase mapping (TPM) enables assessment of regional myocardial velocities. The purpose of this study was to evaluate the impact of regional myocardial fibrosis on regional myocardial velocities. We hypothesize that regional scar will correlate with reduced regional systolic and diastolic velocities.
Highlights
Non-ischemic cardiomyopathy (NICM) is a common cause of left ventricular (LV) dysfunction and may be associated with myocardial fibrosis
Global LV systolic function may underestimate the impact of fibrosis on myocardial function and is insensitive to regional abnormalities in myocardial motion
The purpose of this study was to evaluate the impact of regional myocardial fibrosis on regional myocardial velocities
Summary
Non-ischemic cardiomyopathy (NICM) is a common cause of left ventricular (LV) dysfunction and may be associated with myocardial fibrosis. Global LV systolic function may underestimate the impact of fibrosis on myocardial function and is insensitive to regional abnormalities in myocardial motion. Advances in cardiac MRI have enabled quantification of myocardial fibrosis through the calculation of the gadolinium extracellular volume fraction (Ve) using T1 mapping techniques employing the modified look-locker inversion recovery (MOLLI) correction. Tissue phase mapping (TPM) enables assessment of regional myocardial velocities. The purpose of this study was to evaluate the impact of regional myocardial fibrosis on regional myocardial velocities. We hypothesize that regional scar will correlate with reduced regional systolic and diastolic velocities
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