Abstract
BackgroundBidirectional relationship between migraine and depression suggests that there might be some etiological risk factors shared. However, few studies investigated resting state abnormalities affected by depressive symptoms in migraine patients without aura (MWoA).Materials and MethodsAccording to their self-rating depression scale (SDS) score, MWoA were divided into twenty in the SDS (+) (SDS > 49) group and 20 in the SDS (−) (SDS ≤ 49) group. Regional homogeneity (ReHo) method were employed to assess local features of spontaneous brain activity between 1) all MWoA and healthy controls, 2) each subgroup and healthy controls, and 3) SDS (−) group and SDS (+) group.ResultsCompared with healthy controls, decreased ReHo in similar regions were shown in the MWoA group and subgroups. It is noteworthy that the caudate showed increased ReHo in the SDS (−) group compared with healthy controls and the SDS (+) group. Moreover, the average ReHo values of the caudate in SDS (−) group were significantly positively correlated with duration of migraine.ConclusionsOur results suggested that ReHo patterns in migraine patients may be affected by depressive symptoms and serve as a biomarker to reflect depression severity in MWoA.
Highlights
As a primary headache disorder, migraine may be associated with a number of physiological and emotional stressors and even increase the risk of psychiatric disorders with a variety of psychological characteristics such as depressive symptoms [1]
Regional homogeneity (ReHo) results within the migraine patients without aura (MWoA) and healthy controls are shown in Figure 1 (p < 0.05, FWE corrected)
Compared with healthy controls, decreased ReHo values located in the insula, the rostral anterior cingulate cortex (rACC), the SMA and the cuneus were shown in the whole MWoA group, self-rating depression scale (SDS) (−) group and SDS (+) group (p < 0.05, FWE corrected) (Figure 2 a, b, c), while no brain region with increased ReHo values was observed in the whole MWoA group and SDS (+) group (Figure 2 a, b)
Summary
As a primary headache disorder, migraine may be associated with a number of physiological and emotional stressors and even increase the risk of psychiatric disorders with a variety of psychological characteristics such as depressive symptoms [1]. The spontaneous fluctuations of neuronal activity at the baseline state affected by depressive symptoms in migraine patients remains unclear. Bidirectional relationship between migraine and depression suggests that there might be some etiological risk factors shared. Few studies investigated resting state abnormalities affected by depressive symptoms in migraine patients without aura (MWoA). Regional homogeneity (ReHo) method were employed to assess local features of spontaneous brain activity between 1) all MWoA and healthy controls, 2) each subgroup and healthy controls, and 3) SDS (−) group and SDS (+) group. Results: Compared with healthy controls, decreased ReHo in similar regions were shown in the MWoA group and subgroups.
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