Abstract
This chapter focuses on the regional energy metabolism during maturation and aging of mouse cerebellum. To assess age-related changes in brain chemistry in a systematic way, it would be well to avoid the usual sources of variability encountered in sampling brains of individual animals at various ages, yet allow relatively rapid scanning of the total life span of the species. Most physiological and biochemical parameters are close to adult values and many studies of brain development have followed mice only to the age of 30 days. One of the difficulties in assessing development is the variation that is found even among inbred litters. The effect of severe food deprivation can cause profound retardation of brain development. In the late maturational period, following apparent morphological, physiological, and behavioral maturation of the mouse cerebellum, significant age-related metabolic changes can still be found. These changes are sometimes in opposite directions in different regions and might easily be undetected if the whole cerebellum is studied.
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