Abstract
THE almost universal occurrence of acetylcholine, other choline derivatives and cholinesterase in the vertebrate nervous system, and effects of cholinesterase inhibitors on the central nervous system have suggested that cholinergic systems play an important part in brain function. The experimental evidence for such a role ranges from effects on the rate of discharge of single brain neurones to complex animal behaviour1. Whittaker2 has demonstrated that acetylcholine is located primarily in the specific tissue fraction consisting chiefly of nerve ending particles. De Robertis3 has located acetylcholine in the synaptic vesicles recovered from brain homogenates.
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