Abstract
The effects of ovariectomy and estrogen treatment on hypothalamic LHRH and pituitary and serum LH were studied in female rats. The median eminence (ME) and 13 individual hypothalamic nuclei were removed by microdissection for determination of LHRH by RIA; anterior pituitary and serum LH were also measured by specific RIA. During the morning of proestrus, the highest LHRH concentration was present in the ME with high levels also present in the organum vasculosum of the lamina terminalis (OVLT) and in the retrochiasmatic area. Two weeks after ovariectomy, LHRH in the ME was significantly reduced to 58% of cpntrol. Four weeks after ovariectomy, LHRH in the ME and in the arcuate nucleus was reduced to 36% and 30% of controls, respectively. This progressive reduction of LHRH after ovariectomy was accompanied by parallel mcreases in both pituitary and serum LH. Daily injections of estradiol benzoate (20 /xg/day in oil) for 2 weeks prevented these changes in ovariectomized rats. LHRH in the OVLT was unchanged by...
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