Regional Differences of Guillain-Barré Syndrome in China: From South to North.

Jiajia Yao,Shuping Liu,Zuneng Lu,Yin Liu

doi:10.3389/fnagi.2022.831890

Jiajia Yao, Shuping Liu + Show 2 more

Open Access

https://doi.org/10.3389/fnagi.2022.831890

Copy DOI

Abstract

BackgroundThe epidemiological features of Guillain-Barré syndrome (GBS) were different in different areas; a comparison of the disease was needed to identify the variation and prognosis. We compare the epidemiological features of GBS in different areas in China.MethodA total of 1,191 patients were included. Information was collected in patients diagnosed with GBS and its variants in middle and south China, and then retrospectively reviewed. The patients were divided into four different regions: East China (n = 441), Center China (n = 566), South China (n = 77), and Southwest China (n = 107). These subregions are mainly divided by climate and geographical location. These data were compared with data from a study in East China (Shandong, n = 150) and Northeast China (Changchun, n = 750).ResultsPatients from the south and southwest China were younger than other regions (P = 0.000). A summer peak and an autumn peak were found in northern China, but more patients in winter and spring days in other areas (P = 0.000). Upper respiratory tract infection (URTI) was the preceding event of GBS patients in all regions but rarer in central China (P = 0.001). The proportion of axonal subtype was higher in central and southwest China than in other regions (P = 0.001). Patients in southwest China were more served at nadir and have the longest hospital stay (P = 0.003 and P = 0.000).ConclusionThe difference between seasonal variation and preceding events was found in different regions in China; clinical features differ among regions in China.

Highlights

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy, presenting with muscle weakness and sensory symptoms; regional differences were found worldwide (Hughes and Cornblath, 2005; Greenberg and Vearrier, 2012; Kuwabara and Yuki, 2013; Wakerley et al, 2014; Shahrizaila et al, 2021)
China has a vast territory, and the climate and economic development levels vary from region to region; it is unknown whether it varies in different regions of China
Comparisons of previous studies suggest that the geographical origin of patients with GBS influences the variations of this disease, such as axonal, was the main subtype in Northern China (Ho et al, 1995), and demyelinating was more common in South China, European, and American countries (Hadden et al, 1998; Hughes and Cornblath, 2005; van Doorn et al, 2008; Liu et al, 2018); Europe shows an increased incidence in winter or spring, while India and Latin America receive a significant decrease in winter (Webb et al, 2015)

Summary

Introduction

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy, presenting with muscle weakness and sensory symptoms; regional differences were found worldwide (Hughes and Cornblath, 2005; Greenberg and Vearrier, 2012; Kuwabara and Yuki, 2013; Wakerley et al, 2014; Shahrizaila et al, 2021). Comparisons of previous studies suggest that the geographical origin of patients with GBS influences the variations of this disease, such as axonal, was the main subtype in Northern China (Ho et al, 1995), and demyelinating was more common in South China, European, and American countries (Hadden et al, 1998; Hughes and Cornblath, 2005; van Doorn et al, 2008; Liu et al, 2018); Europe shows an increased incidence in winter or spring, while India and Latin America receive a significant decrease in winter (Webb et al, 2015). The epidemiological features of Guillain-Barré syndrome (GBS) were different in different areas; a comparison of the disease was needed to identify the variation and prognosis. We compare the epidemiological features of GBS in different areas in China

Methods

Results

Discussion

Conclusion