Abstract
By using in situ hybridisation we examined the acute effects of caffeine on haloperidol-induced c- fos mRNA in rat striatum. A homogenous induction of striatal c- fos mRNA was found 30 min after injection of haloperidol (1 mg kg −1). At this timepoint caffeine (40 mg kg −1) did not affect c- fos mRNA in striatum but caused a significant increase of this gene in the somatosensory cortex. When caffeine was injected together with haloperidol c- fos mRNA was reduced in the medial part of the striatum, but enhanced in the caudal part. Similar region-specific effects of caffeine were observed on c- fos mRNA induced by the selective dopamine D 2 antagonist raclopride (0.5 mg kg −1). Both haloperidol and raclopride counteracted caffeine-induced c- fos mRNA expression in somatosensory cortex. By contrast no significant interactions between caffeine and the dopamine D 1 antagonist SCH 23 390 (0.5 mg kg −1) on striatal c- fos mRNA expression were observed. The present data show that caffeine modulates c- fos mRNA induced by dopamine D 2 receptor antagonism differentially in sensorimotor and limbic-related areas of striatum. It is suggested that this could depend upon a different action of caffeine on the cortical inputs to these two parts of the striatum.
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