Abstract
It has been shown that the potency of bicuculline to displace [ 3H]muscimol binding to crude brain membranes can be enhanced markedly by different anions. This study shows that although bicuculline alone was a more potent displacer of [ 3H]muscimol binding in cortical than in cerebellar membranes, the NaCl (250 mM)-induced leftward shift of the bicuculline inhibition curve of [ 3H]muscimol binding was considerably higher in cerebellum than in cortex. The same concentration of NaCl failed to affect either the affinity or the density of cortical and cerebellar [ 3H]muscimol binding sites. The results suggest that sodium chloride is able to reveal regional differences in bicuculline potency.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
