Regional differences in hindgut structure and function in the nutria, Myocastor coypus.

Abstract

Morphologically the large intestine of the nutria resembles that of other caviomorphs, notably the guinea pig. The cecum is voluminous: it contributes 8.6% of the total intestinal length and 12.7% of the total intestinal surface area (considering the surface enlargement factor). It contains 27-32% of the wet ingesta and 20-23% of the dry matter in the gastrointestinal tract. In the colon the corresponding figures are: 21.8% of length, 12.6% of surface area, 16-21% of wet ingesta, and 16-40% of dry matter. The colon can be subdivided both structurally and functionally into two sections, the proximal and the distal colon, the border between the two being the apical flexure of a long parallel loop. The proximal colon (42% of colonic length) displays on the mucosal surface of its mesenterial side a narrow furrow bordered by ridges, which is absent in the distal colon. The ridges contain subepithelial accumulations of coiled tubuloalveolar mucoid glands, entwined by bundles of muscle fibers. Determinations of nitrogen in the contents near the furrow suggest a concentration of bacteria in this part of the lumen. It is hypothesized that the structural differentiations of the proximal colon provide mechanisms for the transport of bacteria from the proximal colon back into the cecum to maintain the fermentation function. The slopes of the longitudinal profiles for dry matter and for concentrations of sodium, potassium and calcium in the luminal contents change at the tip of the parallel loop. The electrical potential difference "intestinal lumen - blood" is particularly large in the proximal colon, indicating active electrogenic ion transport in this region.