Regional coronary venous flow responses to transient coronary artery occlusion in human beings

Abstract

Coronary hemodynamic responses to transient coronary artery occlusion in 21 patients were investigated by using regional coronary venous thermodilution to measure regional coronary venous flows. Transient coronary artery occlusion was produced by coronary artery spasm (13 patients) or balloon inflation during coronary angioplasty (8 patients). The left anterior descending coronary artery was transiently occluded in 12 patients, the right coronary artery in 8 patients and the left circumflex artery in 1 patient. During transient coronary occlusion, regional venous flow decreased in 20 of the 21 patients (79 +/- 31 to 53 +/- 29 ml/min, mean +/- standard deviation [SD]; probability [p] less than 0.05) corresponding to the left ventricular region perfused by the occluded artery. Regional coronary resistance increased in all 21 of these regions (1.42 +/- 0.75 to 2.26 +/- 1.45 mm Hg/ml per min, p less than 0.05). Simultaneously measured blood flow and resistance in the left ventricular region supplied by the nonoccluded arteries did not change significantly (62 +/- 27 to 64 +/- 29 ml/min and 1.85 +/- 0.93 to 1.81 +/- 0.98 mm Hg/ml per min, respectively). Coronary hemodynamic changes were similar during transient coronary occlusion, whether produced by coronary spasm or by balloon inflation. However, the presence of angina, reversible electrocardiographic abnormalities and an increase of the left ventricular filling pressure were more common during coronary spasm (p less than 0.05 for all). Regional coronary hemodynamic changes during transient occlusion of the anterior descending, circumflex or right coronary artery were similar. These data show that coronary occlusion decreases regional left ventricular flow in the region perfused by the affected artery. The method of coronary occlusion or the coronary artery affected during occlusion did not seem to elicit different responses.