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Abstract
Induction chemotherapy for squamous cell carcinomas of the head and neck has been the subject of a number of clinical trials with ambiguous results. Response data from phase II studies suggest a 20–40% complete response rate which has lead to an association between chemotherapy and survival and an improvement in survival when compared to historical controls. Eight separate prospective randomized trials have been published to date. Although these have yet to show an improvement in survival, there are critical flaws in each, which limit their interpretation and leave the role of induction chemotherapy an open question [1].
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