Abstract
The objective of the present study was to use quantitative autoradiography to determine binding densities of serotonin 1A (5-HT 1A) and dopamine (DA) D 2 receptors in alcohol-naive periadolescent P and NP rat pups. P ( n=8) and NP ( n=7) rat pups, 25 days of age, from different litters were used. Coronal brain sections were incubated with 2 nM [ 3H]8-OH-DPAT or 20 nM [ 3H]sulpiride for 5-HT 1A or D 2 binding, respectively. Approximately 15–40% higher densities of [ 3H]8-OH-DPAT binding were observed in the anterior cortical regions of the periadolescent P rat compared with NP rat pups. Similar differences were also observed in posterior cortical regions with P rats having 25–40% higher [ 3H]8-OH-DPAT binding than NP rats. [ 3H]8-OH-DPAT binding was approximately 10–20% higher in posterior hippocampal regions of the P rat pups compared with the NP line. [ 3H]sulpiride binding was significantly different only in the ventral tegmental area (VTA), where binding was approximately 20% lower in the periadolescent P rats compared with the NP rat pups. Overall, these results are very similar to findings observed in adult alcohol-naive P and NP rats, and suggest that the innate differences in the neural systems implicated in high alcohol drinking behaviors may already be established in the periadolescent animal.
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