Abstract
Objective To observe the use of different concentration citrate(30% and 4% ) as regional anticoagulation for hemodialysis under conventional dialysis concentrated solution. Methods A total of 32 patients with high risk hemorrhage in need of sustained hemodialysis were randomly divided into two groups (high concentrations of citrate, n=15 and low concentrations of citrate, n=17). Activated coagulation time(ACT), serum PH, free calcium(iCa2+ ), serum sodium(Na+ ) were observed . Urea clearance rate(URR) and the coagulation in extracorporeal circulation were compared. Results After dialysis, the PH, Na+ concentration in both groups increased significantly (P 0.05), whereas it was prolonged slightly at post dialysis and dialyzer outlet. The ACT, PH, iCa2+ , Na+ and URR did not differ significantly after dialysis in both groups. Conclusions Regional citrate anticoagulation for hemodialysis using a conventional calcium-containing dialysate is safe and effective. Using 30% sodium citrate as regional anticoagulation is much easier and more economical as compare with 4% sodium citrate. Key words: Renal Dialysis; Blood Coagulation; Poncirus
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