Regional Changes in Cerebral Oxygenation During Repeated Passive Movement Measured by Functional Near-infrared Spectroscopy

Kazuhiro Sugawara,Hideaki Onishi,Atsuhiro Tsubaki,Haruna Takai,Yuta Tokunaga,Hiroyuki Tamaki

doi:10.3389/fnhum.2015.00641

Abstract

The aim of this study is to investigate the influence of passive movement repetition frequency at 1.5-Hz and 1-Hz on changes in cerebral oxygenation and assess the temporal properties of these changes using functional near-infrared spectroscopy (fNIRS). No significant differences in systemic hemodynamics were observed between resting and passive movement phases for either 1.5-Hz or 1-Hz trial. Changes in cortical oxygenation as measured by fNIRS in bilateral supplementary motor cortex (SMC), left primary motor cortex (M1), left primary somatosensory cortex (S1), and left posterior association area (PAA) during passive movement of the right index finger revealed greater cortical activity at only 1.5-Hz movement frequency. However, there were no significant differences in the time for peak oxyhemoglobin (oxyHb) among regions (bilateral SMC, 206.4 ± 14.4 s; left M1, 199.1 ± 14.8 s; left S1, 207.3 ± 9.4 s; left PAA, 219.1 ± 10.2 s). Therefore, our results that passive movement above a specific frequency may be required to elicit a changed in cerebral oxygenation, and the times of peak ΔoxyHb did not differ significantly among measured regions.

Highlights

Passive movement of limb segments is widely used in neurorehabilitation for stroke, traumatic brain injury, and neurological disease
In bilateral supplementary motor cortex (SMC) (Figure 5A), both oxyHb and total hemoglobin (totalHb) significantly increased during repetitive passive movement at 1.5-Hz compared with the baseline
We investigated regional changes in cerebral oxygenation during repetitive passive movement at two movement frequencies using functional near-infrared spectroscopy (fNIRS)

Summary

Introduction

Passive movement of limb segments is widely used in neurorehabilitation for stroke, traumatic brain injury, and neurological disease. Numerous studies have measured brain activity following passive movement using functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and electroencephalography (EEG); such studies have revealed that afferent signals from cutaneous mechanoreceptors, muscle spindles, and joint receptors activate the primary somatosensory cortex (S1) and the primary motor area (M1) and supplementary motor cortex. Onishi et al (2013) reported posterior association area (PAA) activation following passive finger movement using MEG. FMRI and PET measured cortical activity after repetitive passive finger movement, whereas EEG and MEG measured them in a short period of time after a single passive movement and not measuring the time-dependent changes during repetitive passive movement. Little is known regarding time-dependent changes in cortical activity during repetitive passive movement

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