Abstract
Summary The changes in free amino acids in the rat brain from 12 to 21 days, and the alterations in their distribution effected when estradiol is administered during a critical developmental period, were studied on a regional basis. The concentration of the glutamate group of amino acids, those involved in intermediary metabolism, increased during periods of rapid brain growth and provided an index of the maturation of discrete brain regions. Those amino acids described as putative inhibitory transmitters decreased in concentration from 12 to 21 days, a period when brain excitability increases. The effects of estradiol on the glutamate group varied with respect to the maturational stage of the specific brain area observed. Estradiol particularly accelerated the increase in concentration of these amino acids in the slower-developing cerebellum suggesting that maturation of this structure was accelerated. Estradiol accelerated the decrease of the putative inhibitory neurotransmitters, a finding we have related to electrophysiological studies in which early administration of estradiol increased the sensitivity of the brain to electrical stimulation.
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