Regional cerebral metabolism in PSAPP double-transgenic mice changes with age and genotype

Abstract

visual cortices known to be preferentially affected in DLB and left ventral striatum/basal forebrain. These exploratory findings suggest that DEB/RBD may correlate with early dopaminergic denervation of ventral striatum/basal forebrain regions, and early involvement of visual cortices that are affected by DLB. Further study is needed to confirm these findings in polysomnographically confirmed RBD patients, and to determine the relative contribution of APOE e4 to these findings, their future progression, and the possibility that they are predictive of future DLB.