Abstract
Since electrical stimulation of neurones may activate not only cell bodies but also neuronal fibres, this study aimed to test a selectively cholinergic neurochemical stimulation of the rat substantia innominata (SI) by the local microinjection of carbachol; the effects of this acetylcholine agonist were compared with glutamate. Cortical and subcortical cerebral blood flow (CBF) were measured in anaesthetized rats with the [ 14C]iodoantipyrine method by the tissue sampling technique immediately following the intracerebral (SI) microinjection of saline, 50 nmol of carbachol or glutamate. Carbachol microinjection into the SI induced a transient but significant vasodilatation in frontoparietal motor (+28%) and temporal (+41%) cortices, that lasted for less than 10 min. Glutamate did not elicit any significant CBF modifications when compared to control rats although a significant interhemispheric asymmetry after microinjection was observed in the frontoparietal motor cortex. This latter observation would suggest that the glutamate-induced cortical response is less pronounced than that elicited by carbachol. Overall, these results demonstrate that a selective cholinergic stimulation of the SI can induce a transient cortical vasodilatation and further confirms the hypothesis of a muscarinic modulation of CBF via this basal structure.
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