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Abstract
Traumatic brain injury (TBI) is caused by a sudden external force and can be very heterogeneous in its manifestation. In this work, we analyse T1-weighted magnetic resonance (MR) brain images that were prospectively acquired from patients who sustained mild to severe TBI. We investigate the potential of a recently proposed automatic segmentation method to support the outcome prediction of TBI. Specifically, we extract meaningful cross-sectional and longitudinal measurements from acute- and chronic-phase MR images. We calculate regional volume and asymmetry features at the acute/subacute stage of the injury (median: 19 days after injury), to predict the disability outcome of 67 patients at the chronic disease stage (median: 229 days after injury). Our results indicate that small structural volumes in the acute stage (e.g. of the hippocampus, accumbens, amygdala) can be strong predictors for unfavourable disease outcome. Further, group differences in atrophy are investigated. We find that patients with unfavourable outcome show increased atrophy. Among patients with severe disability outcome we observed a significantly higher mean reduction of cerebral white matter (3.1%) as compared to patients with low disability outcome (0.7%).
Highlights
With an estimated annual global incidence of 6.8 million cases, traumatic brain injury (TBI) imposes a significant burden on patients, their families, and health services [1, 2]
Individual brain regions of interest (ROI) were extracted from the acute T1w magnetic resonance (MR) images
Features were derived from these ROIs and their potential investigated to discriminate TBI patients according to their outcome severity
Summary
With an estimated annual global incidence of 6.8 million cases, traumatic brain injury (TBI) imposes a significant burden on patients, their families, and health services [1, 2]. TBI is often referred to as the “silent epidemic” as symptoms, such as memory loss or cognitive deficits, tend to be less apparent [3]. Research findings on TBI obtained while doing sports [4] or in military conflicts [5] have increasingly brought the disease into the focus of the public [6]. Regional brain morphometry in TBI from acute- and chronic-phase MRI. Southwest Finland imposed those restrictions and no other local committee has given any restrictions. Interested researchers do not need approval from the Ethics Committee. The Clinical Research Centre and their research lawyers are responsible for checking that the request is in concordance with the original consent, and an official data sharing agreement between the parties has to be made
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