Regional blood flows in the goat latissimus dorsi muscle before and after chronic stimulation.

Abstract

Latissimus dorsi muscle (LDM) regional blood flows were determined in anesthetized goats by using colored microspheres under noncontracting and contracting conditions, either before or after 8-10 wk of chronic muscle stimulation. Surgical dissection of the LDM, leaving only the thoracodorsal artery to supply the muscle, did not alter regional noncontracting blood flows but significantly reduced the normal hyperemic response to muscle contraction in muscle regions (posterior-medial) furthest from the entrance of the thoracodorsal artery. Eight to 10 wk after acute muscle dissection, posterior-medial hyperemic flows were restored. Chronic stimulation of the LDM for 8-10 wk, in either dissected or nondissected muscles, did not alter regional blood flows in noncontracting muscle; however, it significantly reduced hyperemic flows in all muscle regions, although capillary density was increased and the muscle was transformed into a predominantly type I fiber type. These results, coupled with data from previous experiments, suggest that the muscle damage observed in the posterior-medial regions of the LDM after surgical dissection and chronic stimulation may be related to reduced hyperemic flow responses caused by surgical isolation of the muscle.