Abstract
Regional and subcellular distribution of muscarinic cholinergic receptors were investigated in the myocardium of commonly used laboratory animals. The density of receptor sites (expressed in terms of either pmol/g protein or pmol/g tissue), amongst the regions examined, was found much higher in right and left atrium in the case of rat and rabbit whereas for the guinea pig and dog, the distribution was diffuse. However irrespective of the species and/or region studies, the microsomal fraction, amongst the subcellular fractions, showed the highest enrichment of receptors.
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