Regional and long-range neural synchronization abnormality during passive hyperthermia

Abstract

Passive hyperthermia would impair wide-domain cognitive performances (e.g. attention, working memory), which may involve abnormal regional and long-range neural activity. Combining the regional homogeneity (ReHo) and seed-based functional connectivity analysis, this study investigated the regional and long-range neural synchronization abnormality during passive hyperthermia. We acquired the resting-state blood oxygenation level dependent (BOLD) data from twenty-three healthy male participants in two simulated thermal conditions: normothermic condition (NC) with temperature at 25°C for 1 h and hyperthermic condition (HC) with temperature at 50°C for 1 h. After scanning, participants were asked to perform an attention network test (ANT). Relative to NC participants, the participants in HC group exhibited decreased regional neural synchronization in the frontal-occipital cortex, specifically in the left opercular part of inferior frontal gyrus/insula, bilateral middle occipital gyrus, and posterior cingulate cortex/precuneus, but increased one in the left dorsal superior/middle frontal gyrus. Using these significantly differed ReHo clusters as seeds, we further performed functional connectivity analysis and found aberrant long-range neural synchronization in the orbital medial frontal cortex, temporal-parietal junction areas. Further neurobehavioral correlation analysis showed significant positive correlation between the regional ReHo alteration in left dorsolateral superior/middle frontal gyrus and executive control effect. Additionally, the functional connectivity of the orbital medial frontal cortex with the seeds “left superior/middle frontal gyrus” and “posterior cingulate cortex/precuneus” were negatively correlated with the increase of rectal temperature. In current study, the participants showed hyperthermia-induced brain activity disruptions, appearing as altered local ReHo and long-range functional connectivity, which might help understand the relationship between neuronal and circuit activities and physiological thermal sensation and regulation as well as behavioral changes.