Abstract
Purpose: Subchondral bone sclerosis is an established feature of human osteoarthritis (OA). Earlier studies have reported that on the structural level, the sclerosis is characterised by thickened cortical plate and increased trabecular bone volume, while on the material level, it is accompanied by hypo-mineralisation in both cortical and trabecular compartments. However, a comprehensive analysis of subchondral bone microarchitecture and mineralisation based on both regional disease severity and cortical-trabecular compartmentalisation is missing.
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