Abstract
Purpose: Alzheimer disease (AD), involved the abnormal metabolism of β-amyloid and tau, is the major cause of dementia among elderly. Diabetes mellitus (DM) has been identified as a risk factor of AD. Two pathological lesions of AD, Aβ plaques and neurofibrillary tangles, are linked to neuroinflammation and lipid peroxidation, are also induced by abnormal glucose metabolism. Here, we examined the effects of experimental DM in tau transgenic mice Tg601 (overexpressing wild-type human tau) and analyzed the brain regional difference occurred due to DM in AD.
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