Abstract
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Highlights
Exposure to stress increases the risk of developing affective disorders such as depression and posttraumatic stress disorder
We adopted a mouse model of chronic social defeat stress (CSDS) (Golden et al, 2011), in which mice were exposed to an aggressor challenge for 10 days (Figure 1A) and tested for social behavior afterwards
We focused our analysis on the nucleus accumbens (NAc) and the medial
Summary
Exposure to stress increases the risk of developing affective disorders such as depression and posttraumatic stress disorder. There was evidence that, in these animals, the genes that regulate the maturation of oligodendrocytes were more likely to be switched off Taken together, these results may suggest that, in certain animals, social stress disrupts the genetic program that controls how oligodendrocytes develop, potentially leading to neurons communicating less well. The results by Bonnefil et al undercover how changes in non-neuronal cells can at least in part explain differences in the way individuals respond to stress. This knowledge may be useful to design new strategies to foster resilience. We suggest the functional role of region-specific myelination in determining depressive-like social behavior
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