Abstract
Organocatalysts are abundantly used for various transformations, particularly to obtain highly enantio- and diastereomeric pure products by controlling the stereochemistry. These applications of organocatalysts have been the topic of several reviews. Organocatalysts have emerged as one of the very essential areas of research due to their mild reaction conditions, cost-effective nature, non-toxicity, and environmentally benign approach that obviates the need for transition metal catalysts and other toxic reagents. Various types of organocatalysts including amine catalysts, Brønsted acids, and Lewis bases such as N-heterocyclic carbene (NHC) catalysts, cinchona alkaloids, 4-dimethylaminopyridine (DMAP), and hydrogen bond-donating catalysts, have gained renewed interest because of their regioselectivity. In this review, we present recent advances in regiodivergent reactions that are governed by organocatalysts. Additionally, we briefly discuss the reaction pathways of achieving regiodivergent products by changes in conditions such as solvents, additives, or the temperature.
Highlights
Over the past two decades, reactions that rely on organocatalysts have emerged as important catalytic systems in asymmetric and conventional synthesis [1,2,3,4,5,6,7,8,9,10,11,12,13,14]
The use of chiral organic molecules as catalysts enables the synthesis of highly enantio- and diastereomeric pure products, which are of great importance in medicinal and pharmaceutical chemistry [15,16,17,18]
Regardless of whether an electron-withdrawing groups (EWGs) or electron-donating groups (EDGs) was present on the MBH carbonate, the primary allylic SCF3 products formed in excellent yields
Summary
Over the past two decades, reactions that rely on organocatalysts have emerged as important catalytic systems in asymmetric and conventional synthesis [1,2,3,4,5,6,7,8,9,10,11,12,13,14]. Controlling the selectivity of the reactions is one of the popular fields of the research area in synthetic organic chemistry Organocatalysts have made it possible to develop a large number of reactions to synthesize stereoselective [19,20,21,22,23,24,25,26,27,28,29], regioselective [30,31,32,33,34,35,36,37,38,39,40], and chemo-selective [41,42,43,44,45,46,47,48] products.
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