Regio-isomeric isoxazole sulfonates: Synthesis, characterization, electrochemical studies and DNA binding activity

Abstract

The transformation of 3,5-bis hydroxypheny-1,2-isoxazoles to their sulfonate ester derivatives is being described. The synthesis of the products was confirmed using FT-IR, NMR, and X-ray diffraction analysis. Subsequently the electrochemical and DNA binding studies of the synthesized compounds were executed. Electrochemical studies of compounds were carried out using cyclic voltammetry (CV). Results from cyclic voltammetry depicted that the synthesized compounds demonstrate one electron oxidation. CV titrations were employed to study interactions between synthesized isoxazole derivatives and DNA, which revealed intercalative interaction of the synthesized compounds with DNA. Compound 4 exhibited highest DNA interaction with the value of 9.03 × 104 M−1 for the binding constant (K).