Abstract
AbstractHerein we report the regio‐ and stereoselective synthesis of tetrasubstituted alkenes from N‐carbamoyl indoles and alkynes via ruthenium(II)‐catalyzed C−H alkenylation/directing group migration, in which the carbamoyl directing group is endowed with a dual role of auxiliary group and migrating acylation reagent via C−N bond cleavage. This method features broad substrate scope, high atom‐ and step‐economy, good functional group tolerance and mild redox‐neutral conditions at room temperature. A series of structurally diverse tetrasubstituted alkenes were synthesized in good to excellent yields, highlighting the efficiency of this method.
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