Abstract
Reversal of regioselectivity in the catalytic asymmetric conjugate additions of 3-substituted oxindoles to β -nitroenones or β -nitroacrylates was established with chiral scandium catalysts. It enabled the construction of functionalized 3,3-disubstituted oxindoles, including terminal and internal vinyl groups in excellent yields and ee values. Reversal of regioselectivity in the catalytic asymmetric conjugate additions of 3-substituted oxindoles to β -nitroenones or β -nitroacrylates was established with chiral scandium catalysts. It enabled the construction of functionalized 3,3-disubstituted oxindoles, including terminal and internal vinyl groups in excellent yields and ee values.
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