Regenerative und anti-entzündliche Effekte von Betulin-Emulsionen bei gestörter epidermaler Barrierefunktion

Abstract

Betulin emulsions are emulsifier-free water/oil emulsions which can be used on dry, sensitive skin with a damaged epidermal barrier function. After experimental damage of the skin barrier by means of a repetitive washing procedure with 0.1 % sodium lauryl sulphate (SLS) solution, the effect of betulin emulsion, compared with that of aqueous hydrophilic cream NRF, on the regeneration of the damaged skin barrier and its accompanying inflammatory irritation was investigated. After one week’s application, compared with untreated skin, there was a significant increase in the hydration of the stratum corneum at the same time as a reduction of the transepidermal water loss. These results were comparable with those of the aqueous hydrophilic cream NRF tested in the same way as a control. Only with betulin emulsions was it possible to obtain a positive influence on the accompanying inflammatory reaction induced by the washing test, which can be documented as a rise in corial blood flow. We were able to demonstrate a significantly quicker normalisation of blood flow with the two betulin emulsions tested, compared with the untreated areas and those treated with the aqueous hydrophilic cream NRF. From this, we conclude that betulin emulsions have an anti-inflammatory effect, which clearly distinguishes them from the preparation used for comparison. On the basis of the demonstrated regenerative and anti-inflammatory effect of the betulin emulsions investigated, a new alternative is offered for application in skin care and skin protection in cases of reduced epidermal barrier function.