Regenerative Therapies in the Treatment of Intrabony Defects Show High Clinical Efficacy

Abstract

Article Title and Bibliographic Information Periodontal Regeneration – Intrabony Defects: A Systematic Review From the AAP Regeneration Workshop. Kao RT, Nares S, Reynolds MA. J Periodontol 2015;86(Suppl.):S77-S104. Reviewers Francesco Cairo, DDS, Umberto Pagliaro, MD Purpose/Question What is the evidence for periodontal regeneration in intrabony defects related to patient-centered behavioral and systemic considerations, results, tooth mobility, flap design, defect morphology, and surgical complications? What is the evidence for classic regenerative approaches (demineralized freeze-dried bone allograft [DFDBA], GTR, and GTR combined with graft materials), laser-assisted regeneration (LAR), enamel matrix derivatives (EMD) (EMD alone, EMD versus GTR, and EMD combination), and recombinant human platelet-derived growth factor BB (rhPDGF-BB)? What is the optimal timing of regenerative treatment of intrabony defects in relation to orthodontic and endodontic therapy? Source of Funding The authors reported that Dr. Nares has received lecture fees from DENTSPLY (York, Pennsylvania). Dr. Reynolds has received research funding from Millennium Dental Technologies (Cerritos, California) and Zimmer Dental (Carlsbad, California), and is an unpaid consultant for LifeNet Health (Virginia Beach, Virginia); Dr. Kao reported no conflicts of interest related to this review. The 2014 Regeneration Workshop was hosted by the American Academy of Periodontology (AAP) and supported in part by the AAP Foundation, Geistlich Pharma North America, Colgate-Palmolive, and the Osteology Foundation. Type of Study/Design Comprehensive literature review Level of Evidence Level 3: Consensus, disease-oriented evidence Strength of Recommendation Grade Grade C: Consensus, disease-oriented evidence