Abstract
Materials and Methods The electronic databases PubMed and Google Scholar were used to search the literature for relevant studies after applying specific inclusion and exclusion criteria. Studies that fulfilled both the inclusion and exclusion criteria were included in this systematic review. The search was conducted by two independent reviewers following the PRISMA guidelines. Results Only 46 studies that fulfilled both the inclusion and exclusion criteria, which were conducted within the last 10 years, were included in this systematic review. These studies investigated different aspects of regenerative endodontic therapy including different types of scaffolds, intracanal medications, pulpal space/barriers, root maturation stage, follow-up duration, and updated studies on their use in the management of immature necrotic permanent teeth. Conclusions This review concluded the compiled data observed that endodontic regenerative therapy was more efficient in treating immature necrotic permanent teeth and offered a greater advantage that should lead to wider acceptance among endodontists for effective results compared to different treatment options. However, more clinical trials with a standardized protocol and defined clinical, radiographic, and histopathological outcomes with longer follow-up periods are warranted.
Highlights
Regenerative endodontic treatment (RET) is a common category of biologically based endodontic therapy known as revascularization or revitalization; RET aims to promote normal physiological development in immature permanent teeth with pulpal necrosis [1, 2]
Resolution of apical periodontitis, retrogression of associated clinical symptoms, and prolonged survival of teeth are other important outcomes of RET [2,3,4], which are favored in children and young individuals as a viable alternative to traditional endodontic procedures [2]
Biodentin [5,6,7]. e apexification was used as a treatment option for many years, which induces the formation of a calcific barrier at the apex by using intracanal calcium hydroxide (Ca(OH)2)
Summary
Regenerative endodontic treatment (RET) is a common category of biologically based endodontic therapy known as revascularization or revitalization; RET aims to promote normal physiological development in immature permanent teeth with pulpal necrosis [1, 2]. Ese studies include the following information: author and year, animal species, number of subjects (teeth), type of intracanal medication, scaffolds, pulpal space/barrier, root maturation stage, follow-up duration, and main outcomes.
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