Abstract
Ocular chemical and thermal burns are frequent causes of hospitalization and require immediate interventions and care. Various surgical and pharmacological treatment strategies are employed according to damage severity. Controlling inflammation and neovascularization while promoting normal ocular surface anatomy and function restoration is the principal aim. In the most severe cases, when epithelial healing is severely affected, reconstruction of the ocular surface may be a valid option, which, however, requires expertise, adequate instruments, and qualified donors. Numerous endogenous and exogenous strategies have been considered for corneal repair. Among these, stem cells and their derivatives have offered numerous attractive possibilities in finding an effective way in stimulating corneal regeneration. Limbal epithelial stem cells and mesenchymal cells from the ocular tissue as well as from various sources have demonstrated their effectiveness in dampening neovascularization, scarring, and inflammation, while promoting epithelialization of the injured cornea. Moreover, a plethora of cytokines and growth factors, and extracellular vesicles, which constitute the secretome of these cells, work in concert to enhance wound healing. In this review, we provide an update on the recent potential therapeutic avenues and clinical applications of stem cells and their products in corneal regeneration after burn injury, as well as current imaging strategies for monitoring therapeutic efficacy and damage resolution.
Highlights
Stem for rescuing functionsfor host exogenous factors and drugs. Growth cells such as mesenchymal stromal/stem cells (MSCs) of different origin have been hemoderivatives that elicit corneal repair exploiting endogenous mechanisms have shown employed in promises attempts to the damaged cornea
In thisBurn review, we provide an update on the recent potential therapeutic avenues and Injury clinical applications stem with cells and their products in corneal regeneration burn
The term corneal stromal MSCs (CSMSCs) or corneal MSCs has been coined for the Corneal stromal stem cells (CSSCs), which add up to the repertoire of endogenous cells that can repair the cornea upon injury [21]
Summary
Stem for rescuing functionsfor host exogenous factors and drugs Growth cells such as mesenchymal stromal/stem cells (MSCs) of different origin have been hemoderivatives that elicit corneal repair exploiting endogenous mechanisms have shown employed in promises attempts to the damaged cornea. For recent aiming restoration the limbal advances stem cell niche exploited its capacity to knowledgethe gained onafter the burns cell-free suchasasmesenchymal on extracellular vesicles (EVs), regenerate cornea [5].approaches, Stem cells such stromal/stem cells have offered numerous attractive in dampening corneal damagethe and in stim(MSCs) of different origin have alsopossibilities been employed in attempts to regenerate damaged ulating healing. We provide an update the recent gained potential and such as applications on extracellular vesicles haveproducts offered numerous possibilities in clinical of stem cells(EVs), and their in cornealattractive regeneration after burn dampening corneal damage and instrategies stimulating injury, as well as current imaging for healing. In thisBurn review, we provide an update on the recent potential therapeutic avenues and
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
