Abstract
Thymus Chemotherapy and radiation treatments in cancer patients damage a number of tissues and organs, including the thymus. Prolonged thymic damage can lead to T cell deficiency and increased susceptibility to opportunistic infections and malignancies. Wertheimer et al. examined thymic regeneration in mice after sublethal total body radiation. They found a critical role for bone morphogenetic protein 4 (BMP4) signaling in thymic regeneration. Endothelial cells provided a critical source of BMP4, which induces expression of the transcription factor FOXN1 in thymic epithelial cells to promote thymic regeneration. Sci. Immunol. 3 , eaal2736 (2018).
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