Regenerating skeletal muscle: potential diagnostic dilemma in a paediatric patient with a history of rhabdomyosarcoma

Abstract

Skeletal muscle fibre regeneration is a multi-step process that recapitulates muscle embryogenesis.1,2 Satellite cells are myogenic stem cells that are located adjacent to the myofibril and play a crucial role in the regeneration process. Under the right stimuli, they become activated and are capable of proliferation and differentiation towards myocytes, displaying variable morphological appearances.1,2 We present a case of regenerating skeletal muscle in orbital tissue, with the diagnosis made challenging by the patient’s previous history of orbital embryonal rhabdomyosarcoma.