Abstract
Methods Patients underwent regadenoson CMR that included 3 (basal, mid, apical) slices of rest and peak stress real-time cines, with matching stress and rest first-pass perfusion, and late gadolinium enhancement (LGE) imaging. The reference standard for presence or absence of CAD was derived from invasive coronary angiography or coronary CT angiography (CTA). Invasive angiography established significant CAD based on a threshold of ≥70% stenosis and could rule-in or exclude CAD. CTA was only used to exclude CAD if the calcium score was 30%; CT was not used to diagnose CAD. Two blinded, readers qualitatively scored RWM of pre and post-regadenoson.
Highlights
Wall motion abnormalities are central to dobutamine stress CMR but have not been studied with regadenoson
This study was designed to compare the diagnostic performance of regadenoson regional wall motion abnormalities (RWMA) versus first-pass perfusion in the detection of significant coronary artery disease (CAD)
The reference standard for presence or absence of CAD was derived from invasive coronary angiography or coronary CT angiography (CTA)
Summary
Wall motion abnormalities are central to dobutamine stress CMR but have not been studied with regadenoson. This study was designed to compare the diagnostic performance of regadenoson regional wall motion abnormalities (RWMA) versus first-pass perfusion in the detection of significant coronary artery disease (CAD)
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