Abstract
Background Cardiovascular disease is the leading cause of mortality in type 1 diabetics (T1D). T1D patients have increased coronary artery calcification (CAC) compared to nondiabetics. We hypothesize that myocardial blood flow (MBF) reserve can be measured in long-standing T1D patients using regadenoson stress cardiac magnetic resonance (CMR) perfusion imaging and is a marker of extensive atherosclerotic disease associated with CAC.
Highlights
Cardiovascular disease is the leading cause of mortality in type 1 diabetics (T1D)
We hypothesize that myocardial blood flow (MBF) reserve can be measured in long-standing T1D patients using regadenoson stress cardiac magnetic resonance (CMR) perfusion imaging and is a marker of extensive atherosclerotic disease associated with CAC
RABIT1D is a sub-study of the Coronary Artery Calcification in Type 1 Diabetics (CACTI) study that established a cohort of 656 T1D patients and 764 non-diabetic controls that was followed for progression of CAC over 6 years with electron beam tomography
Summary
Cardiovascular disease is the leading cause of mortality in type 1 diabetics (T1D). T1D patients have increased coronary artery calcification (CAC) compared to nondiabetics. We hypothesize that myocardial blood flow (MBF) reserve can be measured in long-standing T1D patients using regadenoson stress cardiac magnetic resonance (CMR) perfusion imaging and is a marker of extensive atherosclerotic disease associated with CAC
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